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Fostamatinib Disodium
CAS NO.: 1025687-58-4
Chemical Formula: C23H24FN6Na2O9P
Molecular Weight: 624.4000
DMF&GMP status: Please contact us for more details.
Description:
Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.

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Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
FOSTAMATINIB DISODIUMTABLET;ORALEQ 100MG BASETAVALISSERIGEL PHARMACEUTICALS INC
FOSTAMATINIB DISODIUMTABLET;ORALEQ 150MG BASETAVALISSERIGEL PHARMACEUTICALS INC
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
N.A.N.A.N.A.N.A.N.A.
Exclusive Data
Exclusivity Code Exclusivity Expiration
NCE 04/17/2023
ODE-174 04/17/2025