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Ambrisentan | CAS 177036-94-1
CAS NO.: 177036-94-1
Chemical Formula: C22H22N2O4
Molecular Weight: 378.4210
DMF&GMP status: Please contact us for details
Description:
Ambrisentan prevents thickening of the blood vessels, especially those in the lungs and heart. Ambrisentan also lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

Ambrisentan is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse. Ambrisentan is sometimes used with a medicine called tadalafil (Adcirca).

Ambrisentan is available only from a certified pharmacy under a special program called LEAP (Letairis Education and Access Program). You must be registered in the program and sign agreements to use birth control and undergo pregnancy and blood testing.
Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
AMBRISENTANTABLET; ORAL10MG LETAIRISGILEAD
AMBRISENTAN TABLET; ORAL 5MG LETAIRIS GILEAD
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
584072224-Nov-15U - 821
5840722 24-Nov-15 U - 1297
7109205 7-Oct-15 Y Y
7601730 7-Oct-15 U - 1080
8349843 7-Oct-15 Y Y
8377933 11-Dec-27 U - 1754
RE42462 29-Jul-18 Y
Exclusive Data
Exclusivity Code Exclusivity Expiration
I - 716 Oct 2
2018