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Dactinomycin, Injection
CAS NO.: 50-76-0
Chemical Formula: C62H86N12O16
Molecular Weight: 1255.4000
DMF&GMP status: Please contact us for more details.
Description:
Mechanism of Action
Dactinomycin for injection is a cytotoxic actinomycin that binds DNA and inhibits RNA synthesis. The cytotoxic activity of dactinomycin has been demonstrated in animal models of different human cancers.

Pharmacodynamics
Dactinomycin exposure-response relationships and the time course of pharmacodynamics response are unknown.

Pharmacokinetics
The distribution and excretion of radiolabeled dactinomycin ( 3H actinomycin D) were assessed in three adult patients with malignant melanoma.

Drug Interaction Studies
Published in vitro studies report that dactinomycin may be a substrate of the P-glycoprotein and OATP1B3 transporter systems.

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Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
DACTINOMYCININJECTABLE;INJECTIONPlease contact us for more detailsPlease contact us for more detailsPlease contact us for more details
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
N.A.N.A.N.A.N.A.N.A.
Exclusive Data
Exclusivity Code Exclusivity Expiration
N.A. N.A.