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CAS NO.: 1448347-49-6
Chemical Formula: C28H22ClF3N6O3
Molecular Weight: 583.0000
DMF&GMP status: Please contact us for more details.
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG.

Ivosidenib is an orally available small molecule inhibitor of isocitrate dehydrogenase 2 which is used as an antineoplastic agent in the treatment of selected cases of acute myeloid leukemia (AML). Ivosidenib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to be the cause of rare instances of clinically apparent acute liver injury.

Ivosidenib is a tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation. It has a role as an antineoplastic agent and an EC (isocitrate dehydrogenase) inhibitor. It is a member of monochlorobenzenes, a cyanopyridine, a member of pyrrolidin-2-ones, an organofluorine compound, a tertiary carboxamide and a secondary carboxamide.

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Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
947477908/19/2033DSDPU-2350 U-2533 U-2534
985027701/18/2033DSDPU-2350 U-2533 U-2534
996859503/13/2035DPU-2350 U-2533 U-2534
1061012506/21/2030U-2784 U-2785
1079949003/13/2035DPU-2981 U-2982
Exclusive Data
Exclusivity Code Exclusivity Expiration
I-816 05/02/2022
NCE 07/20/2023
ODE-203 07/20/2025
ODE-242 05/02/2026