Get a Quote

Mycophenolate Mofetil, Tablet/Capsule
CAS NO.: 128794-94-5
Chemical Formula: C23H31NO7
Molecular Weight: 433.5000
DMF&GMP status: Please contact us for more details.
Description:
Mechanism of Action
Mycophenolate mofetil (MMF) is absorbed following oral administration and hydrolyzed to mycophenolic acid (MPA), the active metabolite. MPA is a selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, MPA has potent cytostatic effects on lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. MPA also suppresses antibody formation by B-lymphocytes. MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. MMF did not inhibit early events in the activation of human peripheral blood mononuclear cells, such as the production of interleukin-1 (IL-1) and interleukin-2 (IL-2), but did block the coupling of these events to DNA synthesis and proliferation.

**Please noted, we do not sell medicines to Individuals. Our products are for Pharmaceutical Companies, Wholesalers, Research Organization and Institutes. A safe online Medicine store should have License by the state board of pharmacy, have a licensed pharmacist, require a prescription and more. For instructions about how to purchase the medicines online, please review FDA official website.
Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
MYCOPHENOLATE MOFETILTABLET;ORALPlease contact us for more detailsPlease contact us for more detailsPlease contact us for more details
MYCOPHENOLATE MOFETILCAPSULE;ORALPlease contact us for more detailsPlease contact us for more detailsPlease contact us for more details
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
N.A.N.A.N.A.N.A.N.A.
Exclusive Data
Exclusivity Code Exclusivity Expiration
N.A. N.A.