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OLICERIDINE
CAS NO.: 1401028-24-7
Chemical Formula: C22H30N2O2S
Molecular Weight: 386.6000
DMF&GMP status: Please contact us for more details.
Description:
OLICERIDINE (TRV130) is an opioid medication that is used for the treatment of moderate to severe acute pain in adults.

OLICERIDINE (TRV130) is indicated for short-term intravenous use in hospitals or other controlled clinical settings, such as during inpatient and outpatient procedures. It is not indicated for at-home use.

OLICERIDINE (TRV130) is a μ-opioid receptor biased agonist developed by Trevena. In cell-based (in vitro) research, oliceridine elicits robust G protein signaling, with potency and efficacy similar to that of morphine, but with less β-arrestin 2 recruitment and receptor internalization. However, recent reports highlight that this might be due to its low intrinsic efficacy, rather than functional selectivity or 'G protein bias' as initially reported. In vivo, it may have fewer adverse effects (including respiratory depression and constipation) compared with morphine. In general, in vitro potency does not guarantee any clinical relevance in humans.

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Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
OLICERIDINESOLUTION;INTRAVENOUS1MG/ML (1MG/ML)OLINVYKTREVENA INC
OLICERIDINESOLUTION;INTRAVENOUS2MG/2ML (1MG/ML)OLINVYKTREVENA INC
OLICERIDINESOLUTION;INTRAVENOUS30MG/30ML (1MG/ML)OLINVYKTREVENA INC
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
N.A.N.A.N.A.N.A.N.A.
Exclusive Data
Exclusivity Code Exclusivity Expiration
N.A. N.A.