Get a Quote

Irinotecan Hydrochloride, Injection
CAS NO.: 100286-90-6
Chemical Formula: C33H39ClN4O6
Molecular Weight: 623.1000
DMF&GMP status: Please contact us for more details.
Description:
Mechanism of Action
Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I, which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks.


**Please noted, we do not sell medicines to Individuals. Our products are for Pharmaceutical Companies, Wholesalers, Research Organization and Institutes. A safe online Medicine store should have License by the state board of pharmacy, have a licensed pharmacist, require a prescription and more. For instructions about how to purchase the medicines online, please review FDA official website.
Approvals
Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
IRINOTECAN HYDROCHLORIDEINJECTABLE;INJECTIONPlease contact us for more detailsPlease contact us for more detailsPlease contact us for more details
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
N.A.N.A.N.A.N.A.N.A.
Exclusive Data
Exclusivity Code Exclusivity Expiration
N.A. N.A.