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Pitolisant Hydrochloride
CAS NO.: 903576-44-3
Chemical Formula: C17H27Cl2NO
Molecular Weight: 332.3000
DMF&GMP status: Please contact us for more details.
Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnagogic hallucinations. About 60-70% of patients with narcolepsy experience cataplexy, which is a sudden loss of muscle tone triggered by positive or negative emotions. Histaminergic neuron signalling in the brain plays a role in maintaining wakefulness; by blocking histamine autoreceptors, pitolisant enhances the activity of histaminergic neurons, as well as increasing the signalling of other neurotransmitters in the brain. In a European clinical trial of adult patients with narcolepsy, there was a reduction in the Epworth Sleepiness Scale (ESS) score from pitolisant therapy compared to placebo. The therapeutic effectiveness of pitolisant was comparable to that of [modafinil]. Pitolisant therapy was also effective in treating refractory sleepiness in adolescent patients with narcolepsy, where it decreased ESS score and increased the mean sleep onset latency. Adolescent patients with cataplexy also experienced a slight improvement in the frequency and severity of symptoms; however, the safety of use in adolescent or paediatric patients have not been established with pitolisant. Commonly marketed under the trade name Wakix, oral pitolisant was approved by the EMA in 2016 for the treatment of narcolepsy with or without cataplexy. FDA approved the use of pitolisant in 2019 for excessive daytime sleepiness (EDS) associated with narcolepsy in adults.

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Active Ingredient Dosage Form; Route Strength Proprietary Name Applicant
Patent Data
Patent No. Patent Expiration Drug Substance Claim Drug Product Claim Patent Use Code
791060509/23/2022U-1101 U-1102
835443002/06/2026U-1101 U-1102
848694709/26/2029U-1101 U-1102
Exclusive Data
Exclusivity Code Exclusivity Expiration
I-846 10/13/2023
NCE 08/14/2024
ODE-255 08/14/2026